This therapeutic method is quite common in aesthetic medicine. By means of multi-injectors fitted with ultra-thin, jagged, no more than 5 mm long needles, various types of pharmaceutical substances are injected into sub-dermal tissues. Its therapeutical goal is to inject substances that can reduce the fibrotic component of suprafascial tissues, thus enhancing microcirculation fluid exchange. In lymphology, in particular, it is only applied in patients with both lipedema and Edematous-Fibrosclerotic Panniculopathy (EFP, see), most commonly in the gluteal region and the hips. Since it is a relatively invasive treatment, and considering the poor outcome in patients with fibrosis due to chronic lymphatic stasis, it should not be used indiscriminately.