Protein molecules, produced by eukaryotic organisms, capable, through different mechanisms, of stimulating growth and differentiation of various tissues. VEGF-C or VEGF-2 (Vascular Endothelial Growth Factor-C or -2) have been identified as specific lymphatic endothelium growth factors. They exert their action by means of endothelial cell-specific receptor tyrosine-kinases, such as flk1/kDR, flt1, and flt4. Several experimental studies are currently under way to reproduce lymphangiogenesis both in vitro and in vivo, in order to better understand any tumor metastasis implications and their role in lymphatic-lymph node dysplasia.